{"id":5316,"date":"2026-06-15T15:07:44","date_gmt":"2026-06-15T19:07:44","guid":{"rendered":"https:\/\/conscience.ca\/?post_type=event&p=5316"},"modified":"2026-06-15T15:10:42","modified_gmt":"2026-06-15T19:10:42","slug":"defi-de-decouverte-de-medicaments-dream-x-cache-target-2035","status":"publish","type":"event","link":"https:\/\/conscience.ca\/fr\/event\/defi-de-decouverte-de-medicaments-dream-x-cache-target-2035\/","title":{"rendered":"D\u00e9fi de d\u00e9couverte de m\u00e9dicaments DREAM x CACHE Target 2035"},"content":{"rendered":"\n
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Nous avons le plaisir d’annoncer le lancement du concours \u00ab DREAM x d\u00e9fi CACHE Target 2035 Drug Discovery Challenge \u00bb, qui est d\u00e9sormais ouvert aux candidatures.<\/p>\n\n\n\n

S’inscrivant dans le cadre de l’initiative Target 2035<\/a>, ce d\u00e9fi, qui succ\u00e8de au premier DREAM Target 2035 Drug Discovery Challenge<\/a>, est rendu possible gr\u00e2ce \u00e0 une collaboration entre le Structural Genomics Consortium (SGC), les laboratoires de Damian Young au Baylor College of Medicine et de Neelagandan Kamariah \u00e0 InStem, IBM (DREAM) et Sage Bionetworks, avec le soutien logistique et technique de Conscience et BEACON. Toutes les donn\u00e9es et tous les r\u00e9sultats seront partag\u00e9s ouvertement et publiquement.<\/p>\n\n\n\n

Le d\u00e9fi scientifique<\/h1>\n\n\n\n

Dans le cadre de ce d\u00e9fi DEL-ML, les participants sont invit\u00e9s \u00e0 pr\u00e9dire, de mani\u00e8re r\u00e9trospective et prospective, les petites mol\u00e9cules qui se lient \u00e0 la phosphoglyc\u00e9rate kinase 2 (PGK2), une enzyme essentielle \u00e0 la motilit\u00e9 des spermatozo\u00efdes et une cible prometteuse pour la contraception non hormonale.<\/p>\n\n\n\n

Les participants ont acc\u00e8s \u00e0 toutes les structures chimiques et aux donn\u00e9es de liaison \u00e0 la PGK2 issues d’un criblage de la biblioth\u00e8que DEL (DNA-encoded library) comprenant pr\u00e8s d’un milliard de compos\u00e9s, sur lesquelles ils peuvent entra\u00eener leurs mod\u00e8les d’apprentissage automatique (ML). Ils doivent ensuite utiliser leurs mod\u00e8les pour extraire r\u00e9trospectivement les hits d’un criblage par spectrom\u00e9trie de masse \u00e0 s\u00e9lection d’affinit\u00e9 (ASMS) de 400 000 compos\u00e9s qui ont \u00e9t\u00e9 confirm\u00e9s par un test de kinase.<\/p>\n\n\n\n

Les participants qui auront identifi\u00e9 l\u2019ensemble le plus diversifi\u00e9 de r\u00e9sultats cach\u00e9s seront ensuite invit\u00e9s \u00e0 pr\u00e9dire de mani\u00e8re prospective de nouveaux r\u00e9sultats \u00e0 partir du catalogue d\u2019Enamine, qui seront ensuite achet\u00e9s et test\u00e9s exp\u00e9rimentalement.<\/p>\n\n\n\n

Les laur\u00e9ats du d\u00e9fi seront d\u00e9termin\u00e9s en fonction du nombre de nouvelles s\u00e9ries chimiques identifi\u00e9es \u00e0 partir de l\u2019ensemble de test et du nombre total de r\u00e9sultats, tel que d\u00e9termin\u00e9 lors de la phase prospective du d\u00e9fi.<\/p>\n\n\n\n

Co\u00fbt de participation<\/h1>\n\n\n\n

La participation \u00e0 la phase r\u00e9trospective du d\u00e9fi est gratuite.<\/p>\n\n\n\n

Les 10 meilleurs participants de la phase r\u00e9trospective seront invit\u00e9s \u00e0 passer \u00e0 la phase prospective, au cours de laquelle ils ach\u00e8teront chacun 50 compos\u00e9s disponibles en stock chez Enamine (co\u00fbt total < 1 000 $). Les organisateurs prendront en charge 100 % des co\u00fbts li\u00e9s aux essais exp\u00e9rimentaux des compos\u00e9s.<\/p>\n\n\n\n

Les participants issus de pays \u00e0 revenu faible ou interm\u00e9diaire qui acc\u00e8dent \u00e0 la phase prospective peuvent voir l’ensemble de leurs frais pris en charge par le SGC s’ils font partie du r\u00e9seau MAINFRAME<\/a> Open Science Machine Learning Network for Drug Discovery.<\/p>\n\n\n\n

Participants canadiens<\/h2>\n\n\n\n

Conscience financera jusqu\u2019\u00e0 50 % des co\u00fbts de participation admissibles (y compris la main-d\u2019\u0153uvre directe, l\u2019achat de mat\u00e9riaux directs\/compos\u00e9s, les ressources informatiques et les autres co\u00fbts directs n\u00e9cessaires \u00e0 la r\u00e9alisation des travaux) pour les universitaires et les entreprises canadiennes admissibles (jusqu\u2019\u00e0 75 000 $ pour les PME et 50 000 $ pour les universitaires par phase du d\u00e9fi). Le financement est bas\u00e9 sur le remboursement, ce qui signifie que les co\u00fbts doivent \u00eatre engag\u00e9s et pay\u00e9s avant d’\u00eatre rembours\u00e9s, et que les candidats retenus doivent conclure un accord de b\u00e9n\u00e9ficiaire final avec Conscience.<\/p>\n\n\n\n

Les participants canadiens les plus performants auront la possibilit\u00e9 de voir leurs pr\u00e9dictions test\u00e9es exp\u00e9rimentalement dans un volet prospectif distinct financ\u00e9 par Conscience, m\u00eame s’ils ne se sont pas class\u00e9s parmi les 10 premiers du d\u00e9fi principal. Ces participants ne seront pas inclus dans le classement final du d\u00e9fi principal.<\/p>\n\n\n\n

Comment participer<\/h1>\n\n\n\n

Inscrivez-vous pour participer via la plateforme Synapse en cliquant sur le lien ci-dessous. La premi\u00e8re date limite de soumission des pr\u00e9dictions pour la phase r\u00e9trospective du d\u00e9fi est fix\u00e9e au 15 septembre. Pour en savoir plus sur le d\u00e9fi et poser toutes vos questions, veuillez vous inscrire au webinaire de lancement du d\u00e9fi<\/a>, qui se tiendra sur Zoom le 7 juillet \u00e0 9 h (heure de l’Est) \/ 15 h (heure d’Europe centrale)<\/strong>.<\/p>\n\n\n\n

\n
Soumettez vos pronostics ici<\/a><\/div>\n<\/div>\n\n\n\n

Nous accueillons des participants du monde entier et nous nous engageons \u00e0 promouvoir l’\u00e9quit\u00e9, la diversit\u00e9 et l’inclusion dans le domaine de la d\u00e9couverte de m\u00e9dicaments par des m\u00e9thodes informatiques. Nous encourageons vivement les candidatures de personnes et d’\u00e9quipes issues de groupes sous-repr\u00e9sent\u00e9s au sein de notre communaut\u00e9 de recherche.<\/p>\n\n\n\n

<\/p>\n","protected":false},"featured_media":5330,"template":"","event-type":[53,52],"class_list":["post-5316","event","type-event","status-publish","has-post-thumbnail","hentry","event-type-challenge","event-type-defi"],"acf":[],"yoast_head":"\nD\u00e9fi de d\u00e9couverte de m\u00e9dicaments DREAM x CACHE Target 2035 - Conscience<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/conscience.ca\/fr\/event\/defi-de-decouverte-de-medicaments-dream-x-cache-target-2035\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"D\u00e9fi de d\u00e9couverte de m\u00e9dicaments DREAM x CACHE Target 2035 - Conscience\" \/>\n<meta property=\"og:description\" content=\"Nous avons le plaisir d’annoncer le lancement du concours \u00ab DREAM x d\u00e9fi CACHE Target 2035 Drug Discovery Challenge \u00bb, qui est d\u00e9sormais ouvert aux candidatures. 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