The CACHE (Critical Assessment of Computation Hit-finding Experiments) Challenges offer an open competition platform to turn drug discovery into a team sport. Researchers from academia, industry, and non-profits are invited to deploy their best AI methods to predict molecules that will bind to an identified target linked to a specific disease. Their predictions are evaluated and benchmarked in a state-of-the-art laboratory, with our partners at the University of Toronto and the Structural Genomics Consortium. All the benchmarked results are shared openly publicly with the world, and verified hits are made available without patent to all.
The results from the first CACHE Challenge were released in January 2024, and included seven verified hits for familial Parkinson’s disease. Many of the top-performing teams presented at the CACHE Symposium, March 6-7 in Toronto.
To learn about past challengers and current opportunities, visit www.cache-challenge.org. To sponsor or support a new challenge, reach out to our partnerships team.
To learn more about the CACHE Challenges, and significance of the results of Challenge 1, check out this piece in Nature Reviews Drug Discovery.
